Nicergoline is an ergoloid mesylate derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. [edit] Interactions Nicergoline is known to enhance the cardiac depressive effects of propranolol (Inderal) - caution is advised. At high dosages, it is advisable to seek one’s physician's guidance if combining with potent vasodilators such as bromocriptine, ginko biloba, hydergine, picamilone, vinpocetine or xanthinol nicotinate.